A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.
Inga svenska synonymer finns.
TACE (Enzyme) — TNF-alpha Converting Enzyme — TNF alpha Converting Enzyme — Tumor Necrosis Factor Alpha Convertase — ADAM-17 — Tumor Necrosis Factor-alpha Converting Enzyme — Tumor Necrosis Factor alpha Converting Enzyme — TNF-alpha Convertase — Convertase, TNF-alpha — TNF alpha Convertase — CD156b Antigen — Antigen, CD156b — ADAM-17 Protein — ADAM 17 Protein — Disintegrin and Metalloproteinase Domain-Containing Protein 17 — Disintegrin and Metalloproteinase Domain Containing Protein 17 — TACA (Enzyme) — Tumor Necrosis Factor-alpha Convertase