En prekursor till amyloid-betaprotein (beta/A4). Förändringar i uttrycket av amyloid-betaproteinprekursorgenen (ABPP-genen), på kromosom 21, spelar en roll vid utvecklingen av neuropatologin i såväl A lzheimers sjukdom som Downs syndrom.
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
Inga svenska synonymer finns.
Amyloid beta Protein Precursor — beta-Protein Precursor, Amyloid — Amyloid beta Precursor Protein — beta-Amyloid Protein Precursor — beta Amyloid Protein Precursor — Protease Nexin II — Nexin II, Protease — Amyloid Protein Precursor — Protease Nexin 2 — Nexin 2, Protease — Amyloid A4 Protein Precursor