Bristfällig utsöndring av vasopressin från neurohypofysen. Kliniska symtom är extrem törst (polydipsi) och nedsatt serumosmolalitet. Tänkbara orsaker kan vara skallskada, sviter av nervkirurgi, hypotalamustumörer, hypofystumörer, infektioner i det centrala nervsystemet, hypofysapoplexi, cerebrovaskulära störningar, granulomatösa sjukdomar (t ex sarkoidos) och andra tillstånd. Sjukdomen kan också vara ärftlig, som ett autosomalt eller recessivt drag.
A genetic or acquired polyuric disorder caused by a deficiency of VASOPRESSINS secreted by the NEUROHYPOPHYSIS. Clinical signs include the excretion of large volumes of dilute URINE; HYPERNATREMIA; THIRST; and polydipsia. Etiologies include HEAD TRAUMA; surgeries and diseases involving the HYPOTHALAMUS and the PITUITARY GLAND. This disorder may also be caused by mutations of genes such as ARVP encoding vasopressin and its corresponding neurophysin (NEUROPHYSINS).
Neurogen diabetes insipidus
Diabetes Insipidus Cranial Type — Diabetes Insipidus Primary Central — Diabetes Insipidus Secondary To Vasopressin Deficiency — Diabetes Insipidus, Central — Diabetes Insipidus, Cranial Type — Diabetes Insipidus, Neurohypophyseal — Diabetes Insipidus, Neurohypophyseal Type — Diabetes Insipidus, Pituitary — Diabetes Insipidus, Primary Central — Neurogenic Diabetes Insipidus — Neurohypophyseal Diabetes Insipidus — Pituitary Diabetes Insipidus — Vasopressin Defective Diabetes Insipidus — Vasopressin Deficiency — Central Diabetes Insipidus