CD40 Antigens

CD40-antigener

Svensk definition

Differentieringsantigener som förekommer på alla mogna B-lymfocyter och vissa epitelceller, karcinom och lymfoida dendritceller. Antigenet ingår i TNF(tumor necrosis factor)-superfamiljen. Det finns b evis för att CD40-beroende aktivering av B-celler har betydelse för bildande av B-minnesceller i lymfkörtlarnas germinalcentra.

Engelsk definition

Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Svenska synonymer

Antigener, CD40 CDw40 antigen

Engelska synonymer

TNFRSF5 Receptor Receptor, TNFRSF5 CDw40 Antigen Antigen, CDw40 Tumor Necrosis Factor Receptor Superfamily, Member 5 CD40 Antigen Antigen, CD40 Antigens, CD40