Receptor, ErbB-2

ErbB-2-receptor

Svensk definition

En cellyterceptor för protein-tyrosinkinas som är överrepresenterad i ett avsevärt antal adenokarcinom. Den har omfattande homologi med och kan bilda heterodimerer med EGF-receptorn (epidermal tillväxtfaktorreceptor), erbB-3-receptorn och erbB-4-receptorn. erbB-2-receptorn aktiveras vid heterodimerbildning med någon ligandbunden erbB-receptor.

Engelsk definition

A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.

Svenska synonymer

Receptor, erbB-2

Engelska synonymer

ErbB-2 Receptor Antigens, CD340 CD340 Antigens Erb-b2 Receptor Tyrosine Kinases Erb b2 Receptor Tyrosine Kinases Proto-Oncogene Proteins c-erbB-2 Proto Oncogene Proteins c erbB 2 p185(c-neu) c-erbB-2 Protein c erbB 2 Protein erbB-2 Proto-Oncogene Protein Proto-Oncogene Protein, erbB-2 erbB 2 Proto Oncogene Protein erbB-2 Receptor Protein-Tyrosine Kinase erbB 2 Receptor Protein Tyrosine Kinase neu Proto-Oncogene Protein Proto-Oncogene Protein, neu neu Proto Oncogene Protein HER-2 Proto-Oncogene Protein HER 2 Proto Oncogene Protein Proto-Oncogene Protein, HER-2 Proto-Oncogene Protein HER-2 Proto Oncogene Protein HER 2 Receptors, erbB-2 erbB-2 Receptors Neu Receptor Receptor, Neu Metastatic Lymph Node Gene 19 Protein Proto-oncogene Protein Neu Tyrosine Kinase-type Cell Surface Receptor HER2 Tyrosine Kinase type Cell Surface Receptor HER2 p185erbB2 Protein CD340 Antigen Oncogene Protein HER-2 Oncogene Protein HER 2 Proto-Oncogene Protein p185(neu)