Svensk definition
Ett syndrom som kännetecknas av svikt i det centrala nervsystemet i förening med leversvikt, inklusive portasystemshuntar. Kliniska tecken är trötthet och förvirring (som ofta leder till koma), asterixis (flaxande rörelser), nystagmus, livliga okulovestibularreflexer, dekortikerad och decerebrerad kroppshållning, muskelryckningar och bilaterala babinskireflexer. EEG kan visa trefasvågor.
Engelsk definition
A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
Svenska synonymer
Leverkoma — Hepatisk encefalopati — Hepatisk stupor — Hepatisk koma — Fulminant leversvikt med cerebralt ödem
Engelska synonymer
Encephalopathies, Hepatic — Hepatic Encephalopathies — Encephalopathy, Hepatic — Portal-Systemic Encephalopathy — Portal Systemic Encephalopathy — Encephalopathy, Portal-Systemic — Encephalopathies, Portal-Systemic — Encephalopathy, Portal Systemic — Portal-Systemic Encephalopathies — Encephalopathy, Portosystemic — Hepatocerebral Encephalopathy — Portosystemic Encephalopathy — Encephalopathies, Portosystemic — Portosystemic Encephalopathies — Encephalopathy, Hepatocerebral — Encephalopathies, Hepatocerebral — Hepatocerebral Encephalopathies — Hepatic Coma — Coma, Hepatic — Comas, Hepatic — Hepatic Comas — Hepatic Stupor — Hepatic Stupors — Stupor, Hepatic — Stupors, Hepatic — Fulminant Hepatic Failure with Cerebral Edema