Svensk definition
Den aktiverade formen av koagulationsfaktor XII. I ett inledande skede i den inre koagulationsprocessen spjälkar kallikrein (tillsammans med kofaktorn högmolekylviktskininogen) faktor XII till XIIa. Faktor XIIa bryts därpå ned ännu mer av kallikrein, plasmin och trypsin i mindre faktor XII-fragment (Hagemanfaktorfragment). Dessa fragment ökar prekallikrein-kallikreinaktiviteten, men minskar prokoagulantverkan hos faktor XII.
Engelsk definition
Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
Svenska synonymer
Inga svenska synonymer finns.
Engelska synonymer
Factor 12A — Activated Factor XII — Coagulation Factor XIIa — Factor XIIa, Coagulation — Blood Coagulation Factor XII, Activated — Prekallikrein Activator — Activator, Prekallikrein — Factor Twelve A — Factor XII, Activated — Hageman-Factor Fragments — Fragments, Hageman-Factor — Hageman Factor Fragments