Svensk definition
En experimentell djurmodell för demyeliniserande sjukdom i det centrala nervsystemet. Inokulation med en emulsion av vit substans i kombination med Freunds adjuvans, myelinbasprotein eller renat centralmyelin utlöser ett T-cellsförmedlat immunsvar riktat mot centralmyelin. De patologiska dragen liknar dem vid multipel skleros, inkluderande perivaskulära och periventrikulära inflammationshärdar och demyelinisering. Subpial (under den mjuka hjärnhinnan) demyelinisering under hjärnhinneinfiltrationer förekommer också, vilket också är ett kännetecken vid akut, disseminerad encefalomyelit. Passiv immunisering med T-celler från ett drabbat djur till ett friskt djur framkallar också detta tillstånd.
Engelsk definition
An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Svenska synonymer
Autoimmun experimentell encefalomyelit — Encefalomyelit, allergisk
Engelska synonymer
Autoimmune Encephalomyelitis, Experimental — Experimental Autoimmune Encephalomyelitis — Encephalomyelitis, Experimental Autoimmune — Experimental Allergic Encephalomyelitis — Allergic Encephalomyelitis, Experimental — Encephalomyelitis, Experimental Allergic — Experimental Allergic Encephalomyelitides — Autoimmune Experimental Encephalomyelitis — Encephalomyelitis, Autoimmune Experimental — Experimental Encephalomyelitis, Autoimmune — Encephalomyelitis, Allergic — Allergic Encephalomyelitis