Pre-B Cell Receptors

Pre-B-cellsreceptorer

Engelsk definition

Membrane proteins in precursor B-LYMPHOCYTES (pre-B Cells). They are composed of membrane-bound MU IMMUNOGLOBULIN HEAVY CHAINS in complex with SURROGATE LIGHT CHAINS instead of conventional IMMUNOGLOBULIN LIGHT CHAINS. Only successful rearrangement of the VDJ segments, at the Ig heavy chain gene locus (IMMUNOGLOBULIN HEAVY CHAIN GENES), will generate mu heavy chains that can pair with surrogate light chains. Thus formation of the pre-B cell receptors is an important checkpoint in the development of mature B cells.

Svenska synonymer

Inga svenska synonymer finns.

Engelska synonymer

Cell Receptors, Pre-B Pre B Cell Receptors Receptors, Pre-B Cell Pre-B Cell Receptor Cell Receptor, Pre-B Pre B Cell Receptor Receptor, Pre-B Cell