Focal Adhesion Kinase 1

p125FAK-protein

Engelsk definition

A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.

Svenska synonymer

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Engelska synonymer

p125FAK Protein Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK Protein Tyrosine Kinase 2 Endogenous Substrate pp120