Svensk definition
En sekvensbesläktad underfamilj av ABC-bärare som aktivt transporterar organiska ämnen. Trots att proteinerna betraktas som bärare av organiska anjoner har en underordnad grupp av proteiner i denna familj visat sig förmedla resistens mot neutrala organiska läkemedel. Deras cellulära funktioner kan ha klinisk betydelse för kemoterapi, eftersom de transporterar en rad olika antitumörmedel. Överproduktion av proteiner av denna klass i tumörer anges som en möjlig orsak till läkemedelsmultiresistens. Trots att de liknar P-glykoproteiner vad gäller funktion, uppvisar proteiner av denna klass liten sekvenshomologi med P-glykoproteinfamiljen.
Engelsk definition
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins.
Svenska synonymer
Inga svenska synonymer finns.
Engelska synonymer
Multidrug Resistance Associated Proteins — Multispecific Organic Anion Transport Proteins — Multidrug Resistance-Associated Protein — Multidrug Resistance Associated Protein — Resistance-Associated Protein, Multidrug — ATP-Binding Cassette, Sub-Family C Proteins — ATP Binding Cassette, Sub Family C Proteins — MOAT Protein — Multispecific Organic Anion Transporter