A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.
PAPP-A
Pregnancy Associated Plasma Protein A — IGFBP-4 Protease — IGFBP 4 Protease — Protease, IGFBP-4 — IGFBP-4-Specific Proteinase — Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease — Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease — PAPP-A — PAPP-alpha — PAPP alpha — Pregnancy Associated alpha Plasma Protein — Pregnancy-Associated alpha-Plasma Protein — IGFBP-4 Metalloproteinase — IGFBP 4 Metalloproteinase — Metalloproteinase, IGFBP-4 — Insulin-Like-Growth Factor Binding Protein-4 Protease — Insulin Like Growth Factor Binding Protein 4 Protease