Svensk definition
En experimentell djurmodell för demyelinerande sjukdom vid Guillain-Barres syndrom. Det mest använda protokollet innebär att djurn injiceras med proteinhomogenat från perifer nervvävnad. Efter ca två veckor utvecklar djuren neuropati som följd av ett T-cellförmedlat immunsvar mot myelin P2-proteinet i perifera nerver. Till de patologiska fynden hör perivaskulär ansamling av makrofager och T-lymfocyter i det perifera nervsystemet, liknande förhållandet vid Guillain-Barres syndrom.
Engelsk definition
An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
Svenska synonymer
Inga svenska synonymer finns.
Engelska synonymer
Experimental Allergic Neuritis — Neuritis, Experimental Allergic — Autoimmune Neuritis, Experimental — Experimental Autoimmune Neuropathy — Autoimmune Neuropathies, Experimental — Autoimmune Neuropathy, Experimental — Experimental Autoimmune Neuropathies — Neuropathies, Experimental Autoimmune — Neuropathy, Experimental Autoimmune — EAN (Experimental Allergic Neuritis) — EAN (Experimental Autoimmune Neuritis) — Neuritis, Experimental Autoimmune — Allergic Neuritis, Experimental — Experimental Autoimmune Neuritis