Receptor, trkA

trkA-receptor

Engelsk definition

A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.

Svenska synonymer

Receptor, trkA

Engelska synonymer

Proto-Oncogene Products c-trk c-trk, Proto-Oncogene Products Proto Oncogene Products c trk Proto-Oncogene Protein trk Proto Oncogene Protein trk trk, Proto-Oncogene Protein gp140(c-TRK) trk Proto-Oncogene Protein Proto-Oncogene Protein, trk trk Proto Oncogene Protein NTRK1 Receptor Receptor, NTRK1 Receptor, Neurotrophic Tyrosine Kinase Type 1 c-trk Protein c trk Protein gp140 c-trk c-trk, gp140 gp140 c trk p140-trkA p140 trkA trk1 Transforming Tryrosine Kinase Neurotrophic Tyrosine Kinase Receptor Type 1 trkA Receptor