Tillstånd orsakat av nervgiftet MPTP, som ger upphov till selektiv förstörelses av nigrostriatala dopaminerga nervceller. Kliniska tecken är irreversibla parkinsonsymtom, som t ex stelhet och bradykinesi (sekundär parkinsonism). MPTP-förgiftning används även i djurmodeller för att studera Parkinsons sjukdom.
A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
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Poisoning, MPTP — Neurotoxicity Syndrome, MPTP — MPTP-Induced Parkinsonism — MPTP Induced Parkinsonism — Parkinsonism, MPTP-Induced — Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine — MPTP Neurotoxicity Syndrome — MPTP Neurotoxicity Syndromes — Neurotoxicity Syndromes, MPTP — MPTP-Induced Degeneration of the Striatum — MPTP Induced Degeneration of the Striatum