Translationsprodukter från fusions-mRNA som fås från bcr-genen och en cellulär abl-gen (c-abl) som translokerats till kromosom 22. Fusionsproteinet p210(bcr-abl) påträffas hos patienter med kronisk myelogen leukemi. Fusionsproteinet p190(bcr-abl) finns hos patienter med akut lymfocytisk leukemi. Aktiveringen av humant c-abl genom kromosomal translokering är i stort sett identisk med aktiveringen av mus-c-abl genom viral translokering i Abelsons musleukemivirus.
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
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Fusion Proteins, bcr abl — Bcr-Abl Tyrosine Kinase — Bcr Abl Tyrosine Kinase — Kinase, Bcr-Abl Tyrosine — Tyrosine Kinase, Bcr-Abl — bcr-abl Fusion Proteins — bcr abl Fusion Proteins — bcr-abl Fusion Protein — Fusion Protein, bcr-abl — Protein, bcr-abl Fusion — bcr abl Fusion Protein — Oncogene Protein p190(bcr-abl) — p190(bcr-abl) Fusion Proteins — Oncogene Protein p230(bcr-abl) — p230(bcr-abl) Fusion Proteins — Oncogene Protein p185(bcr-abl) — p185(bcr-abl) Fusion Proteins — Oncogene Protein p210(bcr-abl) — p210(bcr-abl) Fusion Proteins