Svensk definition
Ett enzym som utgör en huvudkomponent i njurens borstbrämmembran, och som även finns i mindre mängd i hjärnan och andra vävnader. Det katalyserar främst spjälkningen av aminogruppen i hydrofoba rester av insulinets B-kedja samt opioida peptider och andra biologiskt aktiva peptider. Det blockeras primärt av EDTA, fosforamidon och tiorfan och återaktiveras av zink. Neprilysin är identiskt med CALLA-antigenet, en viktig markör vid diagnos av akut lymfocytisk leukemi hos människor. Det har inget samband med växten Calla (Kalla). EC 3.4.24.11.
Engelsk definition
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Svenska synonymer
Inga svenska synonymer finns.
Engelska synonymer
CALLA Antigen — Enkephalinase — Enkephalinase-24.11 — Enkephalinase 24.11 — Kidney-Brush-Border Neutral Proteinase — Kidney Brush Border Neutral Proteinase — Neutral Proteinase, Kidney-Brush-Border — Membrane Metallo-Endopeptidase — Membrane Metallo Endopeptidase — Metallo-Endopeptidase, Membrane — Neutral Endopeptidase — Endopeptidase, Neutral — Neutral Endopeptidase 24.11 — Endopeptidase 24.11, Neutral — Thermolysin-Like Metalloendopeptidase — Metalloendopeptidase, Thermolysin-Like — Thermolysin Like Metalloendopeptidase — YGG-Forming Enzyme — Enzyme, YGG-Forming — YGG Forming Enzyme — Common Acute Lymphoblastic Leukemia Antigens — Antigens, Leukemia, Common Acute Lymphoblastic — Atriopeptidase — CD10 Antigen — Antigen, CD10 — Antigens, CD10 — CD10 Antigens — Endopeptidase-24.11 — Endopeptidase 24.11 — Enkephalin Dipeptidyl Carboxypeptidase — Carboxypeptidase, Enkephalin Dipeptidyl — Dipeptidyl Carboxypeptidase, Enkephalin