Neprilysin

Neprilysin

Svensk definition

Ett enzym som utgör en huvudkomponent i njurens borstbrämmembran, och som även finns i mindre mängd i hjärnan och andra vävnader. Det katalyserar främst spjälkningen av aminogruppen i hydrofoba rester av insulinets B-kedja samt opioida peptider och andra biologiskt aktiva peptider. Det blockeras primärt av EDTA, fosforamidon och tiorfan och återaktiveras av zink. Neprilysin är identiskt med CALLA-antigenet, en viktig markör vid diagnos av akut lymfocytisk leukemi hos människor. Det har inget samband med växten Calla (Kalla). EC 3.4.24.11.

Engelsk definition

Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

Svenska synonymer

Inga svenska synonymer finns.

Engelska synonymer

CALLA Antigen Enkephalinase Enkephalinase-24.11 Enkephalinase 24.11 Kidney-Brush-Border Neutral Proteinase Kidney Brush Border Neutral Proteinase Neutral Proteinase, Kidney-Brush-Border Membrane Metallo-Endopeptidase Membrane Metallo Endopeptidase Metallo-Endopeptidase, Membrane Neutral Endopeptidase Endopeptidase, Neutral Neutral Endopeptidase 24.11 Endopeptidase 24.11, Neutral Thermolysin-Like Metalloendopeptidase Metalloendopeptidase, Thermolysin-Like Thermolysin Like Metalloendopeptidase YGG-Forming Enzyme Enzyme, YGG-Forming YGG Forming Enzyme Common Acute Lymphoblastic Leukemia Antigens Antigens, Leukemia, Common Acute Lymphoblastic Atriopeptidase CD10 Antigen Antigen, CD10 Antigens, CD10 CD10 Antigens Endopeptidase-24.11 Endopeptidase 24.11 Enkephalin Dipeptidyl Carboxypeptidase Carboxypeptidase, Enkephalin Dipeptidyl Dipeptidyl Carboxypeptidase, Enkephalin