En metabolit som isolerats ur odlingar av svampen Aspergillus terreus. Ämnet är ett kraftfullt kolesterolsänkande medel. Det hämmar 3-hydroxi-3-metylglutarylkoenzym A reduktas, som är det mängdreglerande enzymet i kolesterolbiosyntesen. Det stimulerar även produktionen av LDL-receptorer i levern.
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Inga svenska synonymer finns.
Mevinolin — Monacolin K — 6-Methylcompactin — 6 Methylcompactin — MK-803 — MK 803 — MK803 — Mevacor — Lovastatin, (1 alpha(S*))-Isomer — Lovastatin, 1 alpha-Isomer — 1 alpha-Isomer Lovastatin — Lovastatin, 1 alpha Isomer — alpha-Isomer Lovastatin, 1