Epidermal Growth Factor

Epidermal tillväxtfaktor

Svensk definition

En 6 kD-polypeptidtillväxtfaktor som först iakttogs i de submaxillära spottkörtlarna hos möss. Epidermal tillväxtfaktor hos människor isolerades ursprungligen ur urin, då den har förmåga att hämma magsaftsutsöndring, och ämnet kallades urogastron. Faktorn uppvisar ett flertal biologiska effekter, inklusive främjande av tillväxt och differentiering av mesenkym- och epitelceller. Syn. EGF.

Engelsk definition

A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.

Svenska synonymer

EGF Epidermal tillväxtfaktor-urogastron Urogastron

Engelska synonymer

Growth Factor, Epidermal Urogastrone EGF Human Urinary Gastric Inhibitor beta-Urogastrone beta Urogastrone Epidermal Growth Factor-Urogastrone Growth Factor-Urogastrone, Epidermal