En magnesiumberoende IgG-autoantikropp i serum hos patienter med kronisk mesangioproliferativ hypokomplementär glomerulonefrit. Den ger upphov till inaktivering av C3 i den alternativa komplementvägen genom att kklyva C3 i två inaktiva fragment, C3c och C3d, istället för C3b, vilket är det normala.
An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.
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C3 NeF IgG Autoantibody — C3NeF IgG Autoantibodies — C3NeF IgG Autoantibody — Autoantibody, C3NeF IgG — IgG Autoantibody, C3NeF — Complement 3 Nephritic Factor — C3 NeF — C3 NeF IgG Autoantibodies — C 3 Nephritic Factor — C3 Nephritic Factor