Ett cysteinproteinas som finns i många vävnader. Det hydrolyserar en rad olika endogena proteiner, inkl. neuropeptider, cytoskelettproteiner, proteiner i glatt muskulatur, hjärtmuskelvävnad, lever, blodplättar och erytrocyter. Man känner till två underklasser med hög resp. låg känslighet för kalcium. Enzymet tar bort Z-skivorna och M-linjerna från myofibriller, aktiverar fosforylaskinas och nukleotidoberoende proteinkinas.
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
Inga svenska synonymer finns.
Calcium-Activated Protease — Calcium Activated Protease — Protease, Calcium-Activated — Calcium-Dependent Neutral Proteinase — Calcium Dependent Neutral Proteinase — Neutral Proteinase, Calcium-Dependent — Proteinase, Calcium-Dependent Neutral — Calcium-Dependent Neutral Protease — Calcium Dependent Neutral Protease — Neutral Protease, Calcium-Dependent — Protease, Calcium-Dependent Neutral — Desminase — Ca2+-Activated Protease — Ca2+ Activated Protease — Protease, Ca2+-Activated — Calcium-Activated Neutral Proteinase — Calcium Activated Neutral Proteinase — Neutral Proteinase, Calcium-Activated — Proteinase, Calcium-Activated Neutral — Calcium-Activated Neutral Protease — Calcium Activated Neutral Protease — Neutral Protease, Calcium-Activated — Protease, Calcium-Activated Neutral — Calpain II — Calpain I