Anaplastic Lymphoma Kinase

Anaplastiskt lymfomkinas

Engelsk definition

A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.

Svenska synonymer

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Engelska synonymer

NPM-ALK ALK Kinase Nucleophosmin-Anaplastic Lymphoma Kinase Nucleophosmin Anaplastic Lymphoma Kinase ALK Tyrosine Kinase Receptor CD246 Antigen Anaplastic Lymphoma Receptor Tyrosine Kinase