Engelsk definition
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.
Svenska synonymer
Insulinreceptorsubstrat-1 — insulinreceptorsubstrat-4 — insulinreceptorsubstrat-2 — insulinreceptorsubstrat-3
Engelska synonymer
IRS Signaling Adaptor Proteins — Insulin Receptor Substrate-1 Protein — Insulin Receptor Substrate 1 Protein — Insulin Receptor Substrate-1 — Insulin Receptor Substrate 1 — Insulin Receptor Substrate-4 Protein — Insulin Receptor Substrate 4 Protein — Insulin Receptor Substrate-4 — Insulin Receptor Substrate 4 — Insulin Receptor Substrate-2 Protein — Insulin Receptor Substrate 2 Protein — Insulin Receptor Substrate-2 — Insulin Receptor Substrate 2 — Insulin Receptor Substrate-3 Protein — Insulin Receptor Substrate 3 Protein — Insulin Receptor Substrate-3 — Insulin Receptor Substrate 3