Insulin Receptor Substrate Proteins

Insulinreceptorsubstratproteiner

Engelsk definition

A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.

Svenska synonymer

Insulinreceptorsubstrat-1 insulinreceptorsubstrat-4 insulinreceptorsubstrat-2 insulinreceptorsubstrat-3

Engelska synonymer

IRS Signaling Adaptor Proteins Insulin Receptor Substrate-1 Protein Insulin Receptor Substrate 1 Protein Insulin Receptor Substrate-1 Insulin Receptor Substrate 1 Insulin Receptor Substrate-4 Protein Insulin Receptor Substrate 4 Protein Insulin Receptor Substrate-4 Insulin Receptor Substrate 4 Insulin Receptor Substrate-2 Protein Insulin Receptor Substrate 2 Protein Insulin Receptor Substrate-2 Insulin Receptor Substrate 2 Insulin Receptor Substrate-3 Protein Insulin Receptor Substrate 3 Protein Insulin Receptor Substrate-3 Insulin Receptor Substrate 3