En kärnreceptorkoaktivator med specificitet för östrogenreceptorer och progesteronreceptorer. Den har histonacetyltransferasverkan som kan spela en roll vid kromatin-remodellering i samband med kärnreceptorutlöst transkription. Koaktivatorn har påvisats i förhöjda halter i vissa hormonberoende tumörer, som t ex i bröstcancer.
A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER.
NR-koaktivator 3
Thyroid Hormone Receptor Activator Molecule 1 — Amplified in Breast Cancer-1 Protein — Amplified in Breast Cancer 1 Protein — Steroid Receptor Coactivator 3 — Nuclear Receptor Coactivator-3 — Receptor-Associated Coactivator 3 — Receptor Associated Coactivator 3