Zalcitabine

Zalcitabin

Engelsk definition

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.

Svenska synonymer

Dideoxicytidin Hivid

Engelska synonymer

Dideoxycytidine 2',3'-Dideoxycytidine 2',3' Dideoxycytidine ddC (Antiviral) NSC-606170 NSC 606170 NSC606170 Hivid HIVID Roche