Dideoxynucleosides

Dideoxinukleosider

Svensk definition

Nukleosider som förlorat två hydroxigrupper från sockerdelen. De flesta av dessa föreningar har bredspektrumverkan mot retrovirus tack vare sin antimetabola effekt. Nukleosiderna fosforyleras intracellulärt till 5'-trifosfat och hämmar omvänd transkription hos virus genom att bilda kedjeavslutningar.

Engelsk definition

Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.

Svenska synonymer

Inga svenska synonymer finns.

Engelska synonymer

ddNus 2',3'-Dideoxynucleosides 2',3' Dideoxynucleosides Dideoxyribonucleosides