Den aktiverade formen av faktor VIII. B-domänen i faktor VIII spjälkas proteolytiskt med trombin till att bilda faktor VIIIa. Faktor VIIIa uppträder som en icke-kovalent dimer i ett metallbundet (sannolikt kalcium) komplex och verkar som kofaktor vid den enzymatiska aktiveringen av faktor X med faktor IXa. Faktor VIIIa påminner till struktur och uppkomst om faktor Va.
Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.
Inga svenska synonymer finns.
Factor Eight A — Blood Coagulation Factor VIII, Activated — Coagulation Factor VIIIa — Factor VIIIa, Coagulation — Factor VIII, Thrombin-Activated — Factor VIII, Thrombin Activated — Thrombin-Activated Factor VIII — Factor 8A — Factor VIII, Activated — Activated Factor VIII — Factor VIIIa Heavy Chain, 92 kDa Isoform — Factor VIIIa Light Chain — Factor VIIIa Heavy Chain, 200 kDa Isoform