Svensk definition
Delkomponent av komplement 1 som, när den aktiverats av C1q, i sin tur genom proteolytisk klyvning aktiverar delkomponent C1s.
Complement C1r
Komplement 1r
Engelsk definition
A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the changed tertiary structure causes autolytic activation of complement C1r which is cleaved into two chains, A (heavy) and B (light, the serine protease), connected by disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either C1r or C1s is cleaved.
Svenska synonymer
Inga svenska synonymer finns.
Engelska synonymer
C1r, Complement — Complement 1r — Complement Component 1r — Component 1r, Complement — C1r Complement — Complement, C1r