Svensk definition
Ett enzym som katalyserar formeringen av 1,25-dihydroxykolekalciferol från 25-hydroxykolekalciferol. Reaktionen kräver syre, magnesium och NAD(P)H. EC 1.14.13.13.
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
25-hydroxikolecalciferol 1-hydroxylas
Engelsk definition
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Svenska synonymer
Inga svenska synonymer finns.
Engelska synonymer
25 Hydroxyvitamin D3 1 alpha Hydroxylase — 25-Hydroxycholecalciferol 1-Hydroxylase — Calcidiol 1-Monooxygenase — Calcidiol 1 Monooxygenase — 25-Hydroxyvitamin D 1-alpha-Hydroxylase — 1-alpha-Hydroxylase, 25-Hydroxyvitamin D — 25 Hydroxyvitamin D 1 alpha Hydroxylase — 25-Hydroxyvitamin D2 1-hydroxylase — 1-hydroxylase, 25-Hydroxyvitamin D2 — 25 Hydroxyvitamin D2 1 hydroxylase — CYP27B1 — Cytochrome P-450 CYP27B1 — Cytochrome P 450 CYP27B1 — 25-Hydroxyergocalciferol 1-alpha-Hydroxylase — 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol — 25 Hydroxyergocalciferol 1 alpha Hydroxylase — 25-Hydroxycholecalciferol-1-Hydroxylase — 25 Hydroxycholecalciferol 1 Hydroxylase — 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase