25-Hydroxyvitamin D3 1-alpha-Hydroxylase

25-hydroxikolecalciferol 1-hydroxylas

Svensk definition

Ett enzym som katalyserar formeringen av 1,25-dihydroxykolekalciferol från 25-hydroxykolekalciferol. Reaktionen kräver syre, magnesium och NAD(P)H. EC 1.14.13.13.

Engelsk definition

A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).

Svenska synonymer

Inga svenska synonymer finns.

Engelska synonymer

25 Hydroxyvitamin D3 1 alpha Hydroxylase 25-Hydroxycholecalciferol 1-Hydroxylase Calcidiol 1-Monooxygenase Calcidiol 1 Monooxygenase 25-Hydroxyvitamin D 1-alpha-Hydroxylase 1-alpha-Hydroxylase, 25-Hydroxyvitamin D 25 Hydroxyvitamin D 1 alpha Hydroxylase 25-Hydroxyvitamin D2 1-hydroxylase 1-hydroxylase, 25-Hydroxyvitamin D2 25 Hydroxyvitamin D2 1 hydroxylase CYP27B1 Cytochrome P-450 CYP27B1 Cytochrome P 450 CYP27B1 25-Hydroxyergocalciferol 1-alpha-Hydroxylase 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol 25 Hydroxyergocalciferol 1 alpha Hydroxylase 25-Hydroxycholecalciferol-1-Hydroxylase 25 Hydroxycholecalciferol 1 Hydroxylase 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase