A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.
Inga svenska synonymer finns.
Steroid 12 alpha Hydroxylase — Steroid 12-Monooxygenase — Steroid 12-Hydroxylase — Steroid-12-Hydroxylase — Steroid 12 Hydroxylase — CYP8B1 — Sterol 12 alpha-Hydroxylase — 12 alpha-Hydroxylase, Sterol — Sterol 12 alpha Hydroxylase — alpha-Hydroxylase, Sterol 12 — Sterol 12-alpha-Hydroxylase — 12-alpha-Hydroxylase — 12 alpha Hydroxylase — 12alpha-Hydroxylase — 12alpha Hydroxylase — Cytochrome P450 8B1 — Steroid-12-Monooxygenase — Steroid 12 Monooxygenase — Cytochrome P450 CYP8B1