Svensk definition
Ett membranbundet cytokrom P450-enzym, kodat av CYP7, som katalyserar hydroxilering av kolesterol till 7-alfa-hydroxikolesterol, det första steget i gallsyrasyntesen. EC 1.14.13.17.
Cholesterol 7-alpha-Hydroxylase
Kolesterol-7-alfa-monooxygenas
Engelsk definition
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
Svenska synonymer
Inga svenska synonymer finns.
Engelska synonymer
Cholesterol 7 alpha Hydroxylase — Cholesterol 7alpha-Hydroxylase — Cholesterol 7alpha Hydroxylase — Cholesterol-7-Hydroxylase — Cholesterol 7 Hydroxylase — Cytochrome P-450 CYP7 — Cytochrome P 450 CYP7 — CYP7A — Cholesterol 7-alpha-Monooxygenase — Cholesterol 7 alpha Monooxygenase — Cytochrome P450 7 — CYP7 — CYP 7A — CYP 7