Ett enzym som konverterar androgener till östrogener genom desaturering av steroidens A-ring. Enzymkomplexet finns i de östrogenproducerande cellernas endoplasmatiska retikel, i äggstockarna, placenta n, Sertoli- och Leydigcellerna, i fett- och hjärnvävnad. Det utgörs av två komponenter: aromatascytokrom P-450 och NADPH-cytokrom P-450-reduktas. EC 1.14.13.-.
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
Östrogensyntas — CYP 19 protein — Cytokrom P-450 19
Estrogen Synthetase — Estrogen Synthase — Cytochrome P450 19 — CYP19 Protein — Protein, CYP19 — Cytochrome P-450(AROM) — CYP 19 — Cytochrome P-450 CYP19 — Cytochrome P 450 CYP19 — P450AROM — Androstenedione Aromatase — Aromatase, Androstenedione — CYP19