Anesthetics, Local

Lokalbedövningsmedel

Svensk definition

Medel som vid lokal applicering i lämpliga mängder blockerar nervledningsförmågan. De har verkan på alla delar av nervsystemet och på alla typer av nervtrådar. I kontakt med ett nervknippe kan medlen ge både sensorisk och motorisk förlamning i det bedövade området. Verkan är fullständigt reversibel.

Engelsk definition

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.

Svenska synonymer

Lokalanestetika

Engelska synonymer

Local Anesthetics Anesthetics, Conduction-Blocking Anesthetics, Conduction Blocking Conduction-Blocking Anesthetics Conduction Blocking Anesthetics Local Anesthetic Anesthetic, Local Anesthetics, Topical Topical Anesthetics