Axin Signaling Complex

Axin-signaleringskomplex

Engelsk definition

A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.

Svenska synonymer

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Engelska synonymer

Signaling Complex, Axin Axin Signaling Complex Proteins beta-Catenin Destruction Complex Destruction Complex, beta-Catenin beta Catenin Destruction Complex