Engelsk definition
A congenital disorder of CHONDROGENESIS and OSTEOGENESIS characterized by hypoplasia of endochondral bones. In most cases there is a curvature of the long bones especially the TIBIA with dimpling of the skin over the bowed areas, malformation of the pelvis and spine, 11 pairs of ribs, hypoplastic scapulae, club feet, micrognathia, CLEFT PALATE, tracheobronchomalacia, and in some patients male-to-female sex reversal (SEX REVERSAL, GONADAL). Most patients die in the neonatal period of respiratory distress. Campomelic dysplasia is associated with haploinsufficiency of the SOX9 TRANSCRIPTION FACTOR gene.
Svenska synonymer
Campomeliskt syndrom — Acampomel campomel dysplasi
Engelska synonymer
Campomelic Dysplasias — Dysplasia, Campomelic — Dysplasias, Campomelic — Campomelic Syndrome — Campomelic Syndromes — Syndrome, Campomelic — Syndromes, Campomelic — Campomelic Dwarfism — Campomelic Dwarfisms — Dwarfism, Campomelic — Dwarfisms, Campomelic — Cmpd1 Sra1 — Cmpd1 Sra1s — Sra1, Cmpd1 — Sra1s, Cmpd1 — Camptomelic Dysplasia — Camptomelic Dysplasias — Dysplasia, Camptomelic — Dysplasias, Camptomelic — Acampomelic Campomelic Dysplasia — Acampomelic Campomelic Dysplasias — Campomelic Dysplasia, Acampomelic — Campomelic Dysplasias, Acampomelic — Dysplasia, Acampomelic Campomelic — Dysplasias, Acampomelic Campomelic