Perforin

Perforin

Engelsk definition

A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.

Svenska synonymer

Cytolysin

Engelska synonymer

Lymphocyte Pore-Forming Protein Lymphocyte Pore Forming Protein Pore-Forming Protein, Lymphocyte Perforin 1 Cytolysin