Ett transmembranöst, domänbärande matrismetalloproteinas (MMP-14; MTMMP-1). Det syntetiseras som en inaktiv zymogen, som aktiveras genom inverkan av proproteinkonvertaser som t ex furin. MMP-14 spelar en direkt roll vid klyvning av proteiner i det pericellulära grannskapet. Dessutom kan det verka indirekt genom att enzymatiskt aktivera proproteinformen av MMP-15. EC 3.4.24.80.
A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
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Metalloproteinase 14, Matrix — Membrane-Type Matrix Metalloproteinase 1 — Membrane Type Matrix Metalloproteinase 1 — MMP-14 Metalloproteinase — MMP 14 Metalloproteinase — Metalloproteinase, MMP-14 — MT1-MMP — MMP14 Metalloproteinase — Metalloproteinase, MMP14 — MT-MMP-1 — MT1-Matrix Metalloproteinase — MT1 Matrix Metalloproteinase — Metalloproteinase, MT1-Matrix — Membrane-Type 1 Matrix Metalloproteinase — Membrane Type 1 Matrix Metalloproteinase — MMP-X1 Protein — MMP X1 Protein