Homogentisate 1,2-Dioxygenase

Homogentisat-1,2-dioxygenas

Engelsk definition

A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.

Svenska synonymer

Inga svenska synonymer finns.

Engelska synonymer

1,2-Dioxygenase, Homogentisate Homogentisate 1,2 Dioxygenase Homogentisic Acid Oxidase Acid Oxidase, Homogentisic Oxidase, Homogentisic Acid Homogentisate Oxygenase Oxygenase, Homogentisate Homogentisate Dioxygenase Dioxygenase, Homogentisate Homogentisate Oxidase Oxidase, Homogentisate