Svensk definition
Ett intracellulärt signalsystem som omfattar MAP-kinaskaskaderna (trestegs-proteinkinaskaskader). Olika uppströmsaktivatorer, som svarar på extracellulära stimuli, utlöser kaskaderna genom att aktivera den första kaskadmedlemmen, MAP-kinaskinaskinas (MAPKKK). I detta steg fosforyleras mitogenaktiverade proteinkinaskinaser (MAPKK), som i sin tur fosforylerar mitogenaktiverade proteinkinaser (MAPK). Dessa utövar sedan sin verkan på olika mål nedströms till att påverka genuttryck. Hos däggdjur finns det flera bestämda MAP-kinasförlopp, inklusive ERK-processen (extracellulärt signalreglerat kinas), SAPK/JNK-förloppet (stressaktiverat proteinkinas/c-jun) och P38-kinasprocessen. De olika förloppen har vissa gemensamma komponenter, beroende på vilket stimulus som utlöser kaskaden.
Engelsk definition
An intracellular signaling system involving the mitogen-activated protein kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Svenska synonymer
Inga svenska synonymer finns.
Engelska synonymer
ERK1-2 Pathway — ERK1 2 Pathway — ERK1-2 Pathways — Pathway, ERK1-2 — Pathways, ERK1-2 — ERK1 and ERK2 Pathway — p38 Kinase Pathway — Kinase Pathway, p38 — Kinase Pathways, p38 — Pathway, p38 Kinase — Pathways, p38 Kinase — p38 Kinase Pathways — p38 Kinase Signaling Pathway — MAP Kinase Cascade — Cascade, MAP Kinase — Kinase Cascade, MAP — MAP Kinase Cascades — MAP Kinase Signaling Cascades — MAP Kinase Signaling Cascade — MAP Kinase Modules — Module, MAP Kinase — MAP Kinase Module — MAP Kinase Signaling Pathways — MAP Kinase Signaling Pathway — MEK-ERK Pathway — MEK ERK Pathway — MEK-ERK Pathways — Pathway, MEK-ERK — Pathways, MEK-ERK — ERK Signal Tranduction Pathway — ERK Pathway — ERK Pathways — Pathway, ERK — Pathways, ERK — JNK Pathway — JNK Pathways — Pathway, JNK — Pathways, JNK — JNK Signaling Pathway — JNK Signaling Pathways — Pathway, JNK Signaling — Pathways, JNK Signaling — Signaling Pathway, JNK — Signaling Pathways, JNK