Selective Estrogen Receptor Modulators

Selektiva östrogenreceptormodulerare

Engelsk definition

A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)

Svenska synonymer

SERM Selektiva estrogenreceptormodulatorer

Engelska synonymer

SERMs Estrogen Receptor Modulators, Selective Selective Estrogen Receptor Modulator SERM Estrogen Receptor Modulator, Selective