Ett dsRNA-aktiverat, cAMP-oberoende serin/treoninkinas som induceras av interferon. I närvaro av dsRNA och ATP autofosforylerar eIF-2-kinas på ett flertal serin- och treoninrester. Det fosforylerade enzymet katalyserar fosforyleringen av eIF-2's alfaunderenhet, vilket leder till att proteinsyntesen hämmas. EC 2.7.10.-.
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
Inga svenska synonymer finns.
Kinase, eIF-2 — eIF 2 Kinase — eRF, eIF-2 Recycling Factor — eRF, eIF 2 Recycling Factor — Heme-Controlled Inhibitor — Heme Controlled Inhibitor — Inhibitor, Heme-Controlled — Heme-Regulated eIF-2alpha Kinase — Heme Regulated eIF 2alpha Kinase — Kinase, Heme-Regulated eIF-2alpha — eIF-2alpha Kinase, Heme-Regulated — Hemin Controlled Repressor — Controlled Repressor, Hemin — Repressor, Hemin Controlled — p68 Kinase — Kinase, p68 — Self-Phosphorylating Protein Kinase — Kinase, Self-Phosphorylating Protein — Protein Kinase, Self-Phosphorylating — Self Phosphorylating Protein Kinase — TIK Kinase — Kinase, TIK — P68 Protein Kinase — Kinase, P68 Protein — Protein Kinase, P68 — RNA-Dependent Protein Kinase — Kinase, RNA-Dependent Protein — Protein Kinase, RNA-Dependent — RNA Dependent Protein Kinase — p65 Kinase — Kinase, p65 — Protein Kinase PKR — Kinase PKR, Protein — PKR, Protein Kinase — Protein Kinase, RNA Activated — Heme-Controlled Translational Repressor — Heme Controlled Translational Repressor — Repressor, Heme-Controlled Translational — Translational Repressor, Heme-Controlled — Hemin-Controlled Translational Repressor — Hemin Controlled Translational Repressor — Repressor, Hemin-Controlled Translational — Translational Repressor, Hemin-Controlled — DAI Protein Kinase — Kinase, DAI Protein — Protein Kinase, DAI — Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase — Double Stranded RNA Dependent eIF 2 alpha Protein Kinase — Double Stranded RNA-Dependent Kinase (dsl) — dsRNA-Activated Inhibitor — Inhibitor, dsRNA-Activated — dsRNA Activated Inhibitor — DSRNA-Dep Protein Kinase — DSRNA Dep Protein Kinase — Kinase, DSRNA-Dep Protein — Protein Kinase, DSRNA-Dep — eIF-2alpha Kinase — Kinase, eIF-2alpha — eIF 2alpha Kinase — Eukaryotic Initiation Factor 2alpha Kinase — Heme Controlled Repressor — Controlled Repressor, Heme — Repressor, Heme Controlled