von Willebrand Factor

von Willebrands faktor

Engelsk definition

A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.

Svenska synonymer


Engelska synonymer

Factor VIIIR-Ag Factor VIIIR Ag Factor VIIIR-RCo Factor VIIIR RCo Ristocetin-Willebrand Factor Ristocetin Willebrand Factor von Willebrand Protein Factor VIII-Related Antigen Factor VIII Related Antigen Ristocetin Cofactor Plasma Factor VIII Complex