Immunoglobulin J-Chains

Immunglobulin, J-kedja

Svensk definition

Immunglobulinfragment i fraktioner av lätta kedjor hos sekretoriskt immunglobulin A eller polymert immunglobulin M i förhållandet en J-kedja per IgA-dimer eller per IgM-pentamer. J-kedjan är en polypeptid med molekylvikt av ca 17 kD, vars uppgift är att antingen binda samman globulinets komponenter eller föra globuliner genom membran.

Engelsk definition

A 15 kDa "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains.

Svenska synonymer

Inga svenska synonymer finns.

Engelska synonymer

Immunoglobulin J Chains J-Chains, Immunoglobulin J Chains, Immunoglobulin Immunoglobulin J Polypeptide J Polypeptide, Immunoglobulin Polypeptide, Immunoglobulin J Immunoglobulin J-Peptide Immunoglobulin J Peptide J-Peptide, Immunoglobulin Ig J Chains Chains, Ig J J Chains, Ig Ig J-Peptide Ig J Peptide J-Peptide, Ig