Svensk definition
Ett metalloproteinas som bryter ned kollagenets vridna områden i små fragment. Klyvning sker företrädesvis vid -Gly i sekvensen -Pro-Xaa-Gly-Pro-. Sex former (eller två klasser) har isolerats från Clostridium histolyticum som korsreagerar immunologiskt, men som har olika sekvenser och olika specificiteter. Andra varianter har isolerats från Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa och arter av Vibrio och Streptomyces. EC 3.4.24.3.
Engelsk definition
A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
Svenska synonymer
Clostridium histolyticum-kollagenas — Clostridiopeptidas A
Engelska synonymer
Clostridium histolyticum Collagenase — Collagenase, Clostridium histolyticum — Nucleolysin — Collagenase, Microbial — Collalysine — Clostridiopeptidase A — Collagenase Clostridium histolyticum — Clostridium histolyticum, Collagenase — histolyticum, Collagenase Clostridium — Collagenase-Like Peptidase — Collagenase Like Peptidase — Peptidase, Collagenase-Like