Amiloride

Amilorid

Svensk definition

En pyrazinförening som hämmar natriumreabsorbtion genom natriumkanalerna i njurepitelceller. Detta ger upphov till en negativ spänning i cellernas luminalmembran och reducerar utsöndringen av kalium- och vätejoner. Amilorid används tillsammans med diuretika för att minska kaliumförlusten.

Engelsk definition

A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

Svenska synonymer

Midamor Amiloridhydroklorid

Engelska synonymer

Amiduret Trom Trom, Amiduret Amiloberag Midoride Amiloride Hydrochloride, Anhydrous Anhydrous Amiloride Hydrochloride Hydrochloride, Anhydrous Amiloride Kaluril Midamor Modamide Amidal Amiloride Hydrochloride Hydrochloride, Amiloride