En pyrazinförening som hämmar natriumreabsorbtion genom natriumkanalerna i njurepitelceller. Detta ger upphov till en negativ spänning i cellernas luminalmembran och reducerar utsöndringen av kalium- och vätejoner. Amilorid används tillsammans med diuretika för att minska kaliumförlusten.
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Midamor — Amiloridhydroklorid
Midamor — Modamide — Amiloride Hydrochloride — Hydrochloride, Amiloride — Amiloride Hydrochloride, Anhydrous — Anhydrous Amiloride Hydrochloride — Hydrochloride, Anhydrous Amiloride — Amidal — Amiduret Trom — Trom, Amiduret — Amiloberag — Kaluril — Midoride