Adjuvants, Immunologic

Immunmodulerande adjuvanser

Svensk definition

Substanser som förstärker, stimulerar, aktiverar eller modulerar såväl det cellulära som humorala immunsvaret. De klassiska medlen (Freunds adjuvans, BCG, Corynebacterium parvum m fl) innehåller bakteriella antigener. Några är endogena (t ex histamin, interferon, transfer factor, interleukin-1). De kan vara antingen ospecifika eller antigenspecifika.

Engelsk definition

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

Svenska synonymer

Immunstimulerare Immunaktivatorer Adjuvanser, immunomodulerande

Engelska synonymer

Immunostimulant Immunologic Adjuvant Immunopotentiator Immunopotentiators Immunological Adjuvant Adjuvant, Immunological Adjuvant, Immunologic Adjuvants, Immunological Immunological Adjuvants Immunoactivators Immunoadjuvants Immunologic Adjuvants Immunoadjuvant Immunostimulants