DCC Receptor

DCC-receptor

Engelsk definition

A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.

Svenska synonymer

DCC- tumörsuppressorprotein

Engelska synonymer

Receptor, DCC DCC Tumor Suppressor Protein Deleted in Colorectal Carcinoma Protein DCC-Netrin-1 Receptor DCC Netrin 1 Receptor Receptor, DCC-Netrin-1