Werner Syndrome Helicase

Werner syndrom ATP-beroende helikas

Engelsk definition

A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.

Svenska synonymer

RECQ2 protein — RECQ3 protein

Engelska synonymer

Helicase, Werner Syndrome — Werner Syndrome ATP-Dependent Helicase — Werner Syndrome ATP Dependent Helicase — RECQL2 Protein — Werner Syndrome RecQ-Like Helicase — Werner Syndrome RecQ Like Helicase — RECQ3 Protein