Engelsk definition
One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.
Svenska synonymer
Inga svenska synonymer finns.
Engelska synonymer
2C, Protein Phosphatase — Phosphatase 2C, Protein — PPM1 Protein Phosphatases — Phosphatases, PPM1 Protein — Protein Phosphatases, PPM1 — Ptc2 Phosphatase — Phosphatase, Ptc2 — PPM1 Magnesium-Dependent Protein Phosphatases — PPM1 Magnesium Dependent Protein Phosphatases — Protein Phosphatase 2C beta — PP2C beta — beta, PP2C — Ppm1b Phosphatase — Phosphatase, Ppm1b — Protein Phosphatase 2C gamma — PPM1G Phosphatase — Phosphatase, PPM1G — PP2Cgamma — Magnesium-Dependent Protein Phosphatase 2C beta — Magnesium Dependent Protein Phosphatase 2C beta — Protein Phosphatase 2C epsilon — PPM1E Phosphatase — Phosphatase, PPM1E — PP2Cepsilon — Protein Phosphatase 2C delta — Protein Phosphatase 1D Magnesium-Dependent, delta isoform — Protein Phosphatase 1D Magnesium Dependent, delta isoform — PPM1D Phosphatase — Phosphatase, PPM1D